Cefaloridine
| Code | Size | Price |
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| TAR-T19678-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Cefaloridine is a first-generation semisynthetic derivative of cephalosporin C. It is unique among cephalosporins in that it exists as a zwitterion. Cephaloridine was very effective to cure pneumococcal pneumonia. It has a high clinical and bacteriological rate of success in staphylococcal and streptococcal infections.
CAS:
50-59-9
Formula:
C19H17N3O4S2
Molecular Weight:
415.48
Purity:
0.98
SMILES:
[H][C@]12SCC(C[n+]3ccccc3)=C(N1C(=O)[C@H]2NC(=O)Cc1cccs1)C([O-])=O
References
1. Kano T, Kato Y, Ito K, Ogihara T, Kubo Y, Tsuji A. Carnitine/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice. Drug Metab Dispos. 2009 May;37(5):1009-16. doi: 10.1124/dmd.108.025015. Epub 2009 Feb 12. PubMed PMID: 19220985.
2. Rokushima M, Fujisawa K, Furukawa N, Itoh F, Yanagimoto T, Fukushima R, Araki A, Okada M, Torii M, Kato I, Ishizaki J, Omi K. Transcriptomic analysis of nephrotoxicity induced by cephaloridine, a representative cephalosporin antibiotic. Chem Res Toxicol. 2008 Jun;21(6):1186-96. doi: 10.1021/tx800008e. Epub 2008 May 23. PubMed PMID: 18500788.
3. Kohda Y, Matsunaga Y, Yonogi K, Kawai Y, Awaya A, Gemba M. Protective effect of serum thymic factor, FTS, on cephaloridine-induced nephrotoxicity in rats. Biol Pharm Bull. 2005 Nov;28(11):2087-91. PubMed PMID: 16272694.
4. Kawai Y, Kohda Y, Kodawara T, Gemba M. Protective effect of a protein kinase inhibitor on cellular injury induced by cephaloridine in the porcine kidney cell line LLC-PK(1). J Toxicol Sci. 2005 Aug;30(3):157-63. PubMed PMID: 16141650.