5'-O-Tritylthymidine
| Code | Size | Price |
|---|
| TAR-T19906-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
5'-O-Tritylthymidine is a blocker of the formation of the FAK/Mdm-2 complex. 5'-O-Tritylthymidine activates p53 and caspase-8. It also leads to increase detachment and apoptosis in breast and colon cancers.
CAS:
7791-71-1
Formula:
C29H28N2O5
Molecular Weight:
484.55
Purity:
0.98
SMILES:
O=C1NC(C(C)=CN1[C@@H]2O[C@H](COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)[C@@H](O)C2)=O
References
1. Golubovskaya VM, Palma NL, Zheng M, Ho B, Magis A, Ostrov D, Cance WG. A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. Anticancer Agents Med Chem. 2013 May;13(4):532-45. PubMed PMID: 22292771; PubMed Central PMCID: PMC3625481.
2. Liekens S, Bronckaers A, Hern?ndez AI, Priego EM, Casanova E, Camarasa MJ, P?rez-P?rez MJ, Balzarini J. 5'-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis. Mol Pharmacol. 2006 Aug;70(2):501-9. Epub 2006 May 4. PubMed PMID: 16675660.
3. Hern?ndez AI, Balzarini J, Karlsson A, Camarasa MJ, P?rez-P?rez MJ. Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2002 Sep 12;45(19):4254-63. PubMed PMID: 12213066.
4. Capron MA, McEldoon WL, Baenziger NC, Wiemer DF. Structure of a modified nucleoside, 3' alpha-diethylphosphono-3' beta-hydroxy-5'-O-tritylthymidine. Acta Crystallogr C. 1994 Feb 15;50 ( Pt 2):291-4. PubMed PMID: 8148096.