Tadalafil, (6R ,12aS)-
| Code | Size | Price |
|---|
| TAR-T20024-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Tadalafil is a carboline derivative and Phosphodiesterase 5 Inhibitor. It is used primarily to treat Erectile dysfunction, Benign Prostatic Hyperplasia, and Primary Pulmonary Hypertension.
CAS:
171596-27-3
Formula:
C22H19N3O4
Molecular Weight:
389.41
Purity:
0.98
SMILES:
O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O
References
1. Mehanna MM, Domiati S, Chmaisse HN, El Mallah A. Antinociceptive effect of Tadalafil in various pain models: Involvement of opioid receptors and Nitric oxide cyclic GMP pathways. Toxicol Appl Pharmacol. 2018 May 16. pii: S0041-008X(18)30218-7. doi: 10.1016/j.taap.2018.05.013. [Epub ahead of print] PubMed PMID: 29777732.
2. Pantziarka P, Sukhatme V, Crispino S, Bouche G, Meheus L, Sukhatme VP. Repurposing drugs in oncology (ReDO)-selective PDE5 inhibitors as anti-cancer agents. Ecancermedicalscience. 2018 Apr 11;12:824. doi: 10.3332/ecancer.2018.824. eCollection 2018. PubMed PMID: 29743944; PubMed Central PMCID: PMC5931815.
3. Walton RB, Reed LC, Estrada SM, Schmiedecke SS, Villazana-Kretzer DL, Napolitano PG, Ieronimakis N. Evaluation of Sildenafil and Tadalafil for Reversing Constriction of Fetal Arteries in a Human Placenta Perfusion Model. Hypertension. 2018 May 7. pii: HYPERTENSIONAHA.117.10738. doi: 10.1161/HYPERTENSIONAHA.117.10738. [Epub ahead of print] PubMed PMID: 29735634.
4. Bhattar R, Tomar V, Yadav SS, Dhakad DS. Comparison of safety and efficacy of silodosin, solifenacin, tadalafil and their combinations in the treatment of double-J stent- related lower urinary system symptoms: A prospective randomized trial. Turk J Urol. 2018 May;44(3):228-238. doi: 10.5152/tud.2018.50328. Epub 2018 Mar 6. PubMed PMID: 29733797; PubMed Central PMCID: PMC5937643.