FTY720-C2
| Code | Size | Price |
|---|
| TAR-T20153-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
FTY720-C2 is an FTY720 analog. It acts as an effective stimulator of the activity of the protein phosphatase 2A.
CAS:
249289-10-9
Formula:
C21H35NO3
Molecular Weight:
349.515
Purity:
0.98
SMILES:
CCCCCCCCc1ccc(CCC(CO)(CO)NC(C)=O)cc1
References
1. Segura-Ulate I, Belcher TK, Vidal-Martinez G, Vargas-Medrano J, Perez RG. FTY720-derivatives do not induce FTY720-like lymphopenia. J Pharmacol Sci. 2017 Mar;133(3):187-189. doi: 10.1016/j.jphs.2017.02.006. Epub 2017 Feb 17. PubMed PMID: 28363412.
2. Enoru JO, Yang B, Krishnamachari S, Villanueva E, DeMaio W, Watanyar A, Chinnasamy R, Arterburn JB, Perez RG. Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy. PLoS One. 2016 Sep 9;11(9):e0162162. doi: 10.1371/journal.pone.0162162. eCollection 2016. PubMed PMID: 27611691; PubMed Central PMCID: PMC5017749.
3. Vargas-Medrano J, Krishnamachari S, Villanueva E, Godfrey WH, Lou H, Chinnasamy R, Arterburn JB, Perez RG. Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells. ACS Med Chem Lett. 2014 May 27;5(7):782-6. doi: 10.1021/ml500128g. eCollection 2014 Jul 10. PubMed PMID: 25050165; PubMed Central PMCID: PMC4094248.