Bucladesine
| Code | Size | Price |
|---|
| TAR-T20214-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is capable of permeating the cell membrane. Bucladesine is a phosphodiesterase inhibitor. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions.
CAS:
362-74-3
Formula:
C18H24N5O8P
Molecular Weight:
469.391
Purity:
0.98
SMILES:
CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H]2COP(O)(=O)O[C@H]2[C@H]1OC(=O)CCC
References
1. Tabrizian K, Hashemzaei M, Nasiri AA, Najafi S, Amelinia F, Sanati M, Shamshirgaran F, Fanoudi S. Interactive involvement of hippocampal cAMP/PKA and cyclooxygenase-2 signaling pathways in spatial learning in the Morris water maze. Folia Neuropathol. 2018;56(1):58-66. doi: 10.5114/fn.2018.74660. PubMed PMID: 29663741.
2. Aghsami M, Sharifzadeh M, Sepand MR, Yazdankhah M, Seyednejad SA, Pourahmad J. A cAMP analog attenuates beta-amyloid (1-42)-induced mitochondrial dysfunction and spatial learning and memory deficits. Brain Res Bull. 2018 Mar 29;140:34-42. doi: 10.1016/j.brainresbull.2018.03.016. [Epub ahead of print] PubMed PMID: 29605485.
3. Rodrigues AL, Brescia M, Koschinski A, Moreira TH, Cameron RT, Baillie G, Beir?o PSL, Zaccolo M, Cruz JS. Increase in Ca(2+) current by sustained cAMP levels enhances proliferation rate in GH3 cells. Life Sci. 2018 Jan 1;192:144-150. doi: 10.1016/j.lfs.2017.11.040. Epub 2017 Nov 26. PubMed PMID: 29183797.
4. Tamura K, Ishikawa G, Yoshie M, Ohneda W, Nakai A, Takeshita T, Tachikawa E. Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1? secretion in human trophoblasts. J Pharmacol Sci. 2017 Oct;135(2):89-95. doi: 10.1016/j.jphs.2017.09.032. Epub 2017 Oct 6. PubMed PMID: 29056256.