Kazinol B
| Code | Size | Price |
|---|
| TAR-T20232-5mg | 5mg | £1,484.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Kazinol B is a natural isoprenylated flavan. It also stimulates the gene expression and secretion of adiponectin.
CAS:
99624-27-8
Formula:
C30H36O4
Molecular Weight:
460.614
Pathway:
Chromatin/Epigenetic|Immunology/Inflammation|PI3K/Akt/mTOR signaling|Cytoskeletal Signaling
Purity:
0.98
SMILES:
CC(C)=CCc1c(O)c(O)cc(C2=CC=C3CC(=C(O)C=C3O2)C(C)(C)C=C)c1CC=C(C)C
Target:
NO Synthase|Akt|AMPK
References
1. Lee H, Li H, Jeong JH, Noh M, Ryu JH. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6. doi: 10.1016/j.fitote.2016.05.006. Epub 2016 May 17. PubMed PMID: 27223849.
2. Ryu JH, Ahn H, Jin Lee H. Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. Fitoterapia. 2003 Jun;74(4):350-4. PubMed PMID: 12781805.
3. Wang JP, Tsao LT, Raung SL, Lin CN. The signal transduction mechanism involved in kazinol B-stimulated superoxide anion generation in rat neutrophils. Br J Pharmacol. 1998 Oct;125(3):517-25. PubMed PMID: 9806335; PubMed Central PMCID: PMC1565651.
4. Wang JP, Hsu MF, Ko HH, Lin CN. Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):500-9. Epub 2004 Nov 19. PubMed PMID: 15558242.