AG-1478
Code | Size | Price |
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TAR-T2047-5mg | 5mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2047-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2047-10mg | 10mg | £119.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2047-25mg | 25mg | £162.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2047-50mg | 50mg | £237.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2047-100mg | 100mg | £302.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2047-200mg | 200mg | £371.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.
CAS:
153436-53-4
Formula:
C16H14ClN3O2
Molecular Weight:
315.76
Pathway:
Proteases/Proteasome; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Microbiology/Virology; Angiogenesis
Purity:
0.9971
SMILES:
COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
Target:
EGFR; HCV Protease; Influenza Virus; HER; PDGFR
References
1. Levitzki A, et al. Science, 1995, 267(5205), 1782-1788.
2. Han Y, et al. Cancer Res, 1996, 56(17), 3859-3861.
3. Eguchi S, et al. J Biol Chem, 1998, 273(15), 8890-8896.
4. Johns TG, et al. Proc Natl Acad Sci U S A, 2003, 100(26), 15871-15876.
5. Lee FT, et al. Clin Cancer Res, 2005, 11(19 Pt 2), 7080s-7086s.
6. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215.
7. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580.
8. Li S T, Young T H, Huang T W. Poly (ethylene-co-vinyl alcohol) is a suitable substrate for human olfactory neuroepithelial cell differentiation in vitro through a defined regulatory pathway[J]. Acta biomaterialia. 2018 Mar 1;68:204-213.