Cgp 29287
| Code | Size | Price |
|---|
| TAR-T20477-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Cgp 29287 is a primate-specific renin inhibitor. It also has a prolonged duration of action.
CAS:
93287-54-8
Formula:
C72H110N20O15
Molecular Weight:
1495.797
Purity:
0.98
SMILES:
CC[C@H](C)[C@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OC
References
1. Samani NJ, Cumin F, Kelly M, Wood JM. Expression of components of the RAS during prolonged blockade at different levels in primates. Am J Physiol. 1994 Oct;267(4 Pt 1):E612-9. PubMed PMID: 7943312.
2. Humke U, Levens N, Wood J, Hofbauer K. Responses to renin inhibition in conscious primates. Am J Physiol. 1991 Jul;261(1 Pt 2):F179-86. PubMed PMID: 1907105.
3. Nussberger J, Brunner DB, Waeber B, Brunner HR. In vitro renin inhibition to prevent generation of angiotensins during determination of angiotensin I and II. Life Sci. 1988;42(17):1683-8. PubMed PMID: 2835564.
4. de Gasparo MM, Wood JM, Heusser CH. Mechanism of inhibition of human renin by monoclonal antibodies. Hypertension. 1988 Mar;11(3):209-16. PubMed PMID: 3280480.