Lomerizine
| Code | Size | Price |
|---|
| TAR-T20917-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T20917-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T20917-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Lomerizine, a blocker of diphenylmethylpiperazine Ca2+ channel, is used to prevent migraines.
CAS:
101477-55-8
Formula:
C27H30F2N2O3
Molecular Weight:
468.545
Purity:
0.98
SMILES:
COc1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(OC)c1OC
References
1. Ren Y, Liu T, Song G, Hu Y, Liang J. Determination of lomerizine in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 1;947-948:96-102. doi: 10.1016/j.jchromb.2013.12.026. Epub 2013 Dec 26. PubMed PMID: 24412691.
2. Tran LT, Gentil BJ, Sullivan KE, Durham HD. The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43. J Neurochem. 2014 Aug;130(3):455-66. doi: 10.1111/jnc.12738. Epub 2014 May 9. PubMed PMID: 24716897.
3. Ishii M, Katoh H, Takagi M, Kawamura M, Shimizu S. Influence of the Tohoku-Pacific Ocean earthquake and its aftershocks on the response to prophylactic therapy with lomerizine in patients with migraine in Tokyo: a retrospective study. Eur Neurol. 2014;71(5-6):252-8. doi: 10.1159/000357209. Epub 2014 Feb 5. PubMed PMID: 24503777.
4. Ishii M, Katoh H, Kurihara T, Kawamura M, Shimizu S. Characteristics of inconsistent responders to prophylaxis therapy with lomerizine in patients with migraine: a retrospective study in Japan. J Neurol Sci. 2013 Dec 15;335(1-2):118-23. doi: 10.1016/j.jns.2013.09.007. Epub 2013 Sep 12. PubMed PMID: 24074550.