OSW-1
| Code | Size | Price |
|---|
| TAR-T21251-5mg | 5mg | £590.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T21251-10mg | 10mg | £871.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
OSW-1 is a natural broad-range inhibitor to inhibits replication of enterovirus.
CAS:
145075-81-6
Formula:
C47H68O15
Molecular Weight:
873.046
Purity:
0.98
SMILES:
[H][C@@]12C[C@H](O[C@@H]3OC[C@H](O)[C@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4OC(=O)c4ccc(OC)cc4)[C@H]3OC(C)=O)[C@](O)([C@H](C)C(=O)CCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
References
1. Iguchi T, Kuroda M, Naito R, Watanabe T, Matsuo Y, Yokosuka A, Mimaki Y. Cholestane glycosides from Ornithogalum saundersiae bulbs and the induction of apoptosis in HL-60 cells by OSW-1 through a mitochondrial-independent signaling pathway. J Nat Med. 2019 Jan;73(1):131-145. doi: 10.1007/s11418-018-1252-4. Epub 2018 Oct 16. PubMed PMID: 30327993.
2. Mesmin B, Bigay J, Polidori J, Jamecna D, Lacas-Gervais S, Antonny B. Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP. EMBO J. 2017 Nov 2;36(21):3156-3174. doi: 10.15252/embj.201796687. Epub 2017 Oct 4. PubMed PMID: 28978670; PubMed Central PMCID: PMC5666618.
3. Malabed R, Hanashima S, Murata M, Sakurai K. Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins. Biochim Biophys Acta Biomembr. 2017 Dec;1859(12):2516-2525. doi: 10.1016/j.bbamem.2017.09.019. Epub 2017 Sep 22. PubMed PMID: 28947142.
4. Zhang Y, Fang F, Fan K, Zhang Y, Zhang J, Guo H, Yu P, Ma J. Effective cytotoxic activity of OSW-1 on colon cancer by inducing apoptosis in vitro and in vivo. Oncol Rep. 2017 Jun;37(6):3509-3519. doi: 10.3892/or.2017.5582. Epub 2017 Apr 19. PubMed PMID: 28440433.