Aprindine hydrochloride
| Code | Size | Price |
|---|
| TAR-T21373-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T21373-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T21373-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally.
CAS:
33237-74-0
Formula:
C22H31ClN2
Molecular Weight:
358.95
Purity:
0.98
SMILES:
Cl.CCN(CC)CCCN(C1Cc2ccccc2C1)c1ccccc1
References
1. Ozawa M, Komatsu T, Sato Y, Kunugita F, Tachibana H, Tashiro A, Okabayashi H, Nakamura M. Comparison of the effects of bepridil and aprindine for the prevention of atrial fibrillation after cardiac and aortic surgery: A prospective randomized study. J Arrhythm. 2015 Oct;31(5):302-6. doi: 10.1016/j.joa.2015.04.003. Epub 2015 May 16. PubMed PMID: 26550087; PubMed Central PMCID: PMC4600894.
2. Nakatani Y, Sakamoto T, Nishida K, Kataoka N, Yamaguchi Y, Sakabe M, Fujiki A, Mizumaki K, Inoue H. Bepridil enhances aprindine-induced prolongation of atrial effective refractory period in a canine atrial rapid pacing model. J Cardiol. 2015 Nov;66(5):445-50. doi: 10.1016/j.jjcc.2015.06.001. Epub 2015 Jul 7. PubMed PMID: 26162947.
3. Tsuchishita Y, Fukumoto K, Kusumoto M, Ueno K. Relationship between serum aprindine concentration and neurologic side effects in Japanese. Biol Pharm Bull. 2009 Apr;32(4):637-9. PubMed PMID: 19336897.
4. Nogami Y, Takase B, Matsui T, Hattori H, Hamabe A, Fujita M, Ohsuzu F, Ishihara M, Maekara T. Effect of antiarrhythmic agents on heart rate variability indices after myocardial infarction: comparative experimental study of aprindine and procainamide. Biomed Pharmacother. 2005 Oct;59 Suppl 1:S169-73. PubMed PMID: 16275488.