MK-212
| Code | Size | Price |
|---|
| TAR-T21466-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T21466-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T21466-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MK-212 is a 5HT2C-receptor agonist. Intraperitoneal injection of MK-212 in 0.5 and 1.0 mg/kg increased the blood level of corticosterone in mice and reduced their motor activity. In 0.1 and 0.2 mg/kg, the agonist reduced anxiety with no effect on motor activity.
CAS:
64022-27-1
Formula:
C8H11ClN4
Molecular Weight:
198.65
Purity:
0.98
SMILES:
Clc1cncc(n1)N1CCNCC1
References
1. Kozhevnikova LM, Mesitov MV, Moskovtsev AA. [Agonists of 5HT2C-receptors SCH 23390 and MK 212 incresase the force of rat aorta contraction in the presence of vasopressin and angiotensin II]. Patol Fiziol Eksp Ter. 2014 Oct-Dec;(4):17-29. Russian. PubMed PMID: 25980223.
2. Kuznetsova EG, Amstislavskaya TG, Bulygina VV, Tibeikina MA, Popova NK. Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice. Bull Exp Biol Med. 2006 Nov;142(5):594-7. PubMed PMID: 17415471.
3. de Mello Cruz AP, Pinheiro G, Alves SH, Ferreira G, Mendes M, Faria L, Macedo CE, Motta V, Landeira-Fernandez J. Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology (Berl). 2005 Nov;182(3):345-54. Epub 2005 Oct 19. PubMed PMID: 16133141.
4. Halford JC, Lawton CL, Blundell JE. The 5-HT2 receptor agonist MK-212 reduces food intake and increases resting but prevents the behavioural satiety sequence. Pharmacol Biochem Behav. 1997 Jan;56(1):41-6. PubMed PMID: 8981607.