Netropsin
| Code | Size | Price |
|---|
| TAR-T21475-5mg | 5mg | £222.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Netropsin is a basic polypeptide isolated from Streptomyces netropsis with antibiotic and antiviral activity. It is strong, specific binding to A-T areas of DNA is useful to genetics research. Netropsin is active against Gram-negative bacteria and Gram-positive bacteria.
CAS:
1438-30-8
Formula:
C18H26N10O3
Molecular Weight:
430.473
Purity:
0.98
SMILES:
Cn1cc(NC(=O)c2cc(NC(=O)CNC(N)=N)cn2C)cc1C(=O)NCCC(N)=N
References
1. Chung JH, Bhat A, Kim CJ, Yong D, Ryu CM. Combination therapy with polymyxin B and netropsin against clinical isolates of multidrug-resistant Acinetobacter baumannii. Sci Rep. 2016 Jun 16;6:28168. doi: 10.1038/srep28168. PubMed PMID: 27306928; PubMed Central PMCID: PMC4910107.
2. Andronova VL, Grokhovsky SL, Surovaya AN, Gursky GV, Galegov GA. Effect of dimeric netropsin analogue 15Lys-bis-Nt and acyclovir on the reproduction of herpes simplex virus type 1. The search for variants of herpes virus with drug resistance to 15Lys-bis-Nt and acyclovir. Dokl Biochem Biophys. 2015;460:42-6. doi: 10.1134/S1607672915010123. Epub 2015 Mar 13. PubMed PMID: 25772989.
3. Szerszenowicz J, Drozdowska D. Semi-automatic synthesis, antiproliferative activity and DNA-binding properties of new netropsin and bis-netropsin analogues. Molecules. 2014 Jul 31;19(8):11300-15. doi: 10.3390/molecules190811300. PubMed PMID: 25090119.
4. Ramos JP, Le VH, Lewis EA. Role of water in netropsin binding to an A(2)T(2) hairpin DNA site: osmotic stress experiments. J Phys Chem B. 2013 Dec 19;117(50):15958-65. doi: 10.1021/jp408077m. Epub 2013 Dec 5. PubMed PMID: 24274393.