Vacuolin-1

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TargetMol
Product Code: TAR-T21992
Supplier: TargetMol
CodeSizePrice
TAR-T21992-1mg1mg£95.00
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TAR-T21992-5mg5mg£128.00
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TAR-T21992-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T21992-10mg10mg£161.00
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TAR-T21992-25mg25mg£246.00
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TAR-T21992-50mg50mg£389.00
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TAR-T21992-100mg100mg£544.00
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TAR-T21992-500mg500mg£1,099.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin?1 is a potent and selective PIKfyve inhibitor and inhibits late?stage autophagy by impairing lysosomal maturation
CAS:
351986-85-1
Formula:
C26H24IN7O
Molecular Weight:
577.43
Pathway:
PI3K/Akt/mTOR signaling; Autophagy
Purity:
0.9945
SMILES:
Ic1cccc(C=NNc2nc(nc(n2)N2CCOCC2)N(c2ccccc2)c2ccccc2)c1
Target:
PI3K; Autophagy

References

1. Yingying Lu, et al. Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. Autophagy 2. Osamu Sano, et al. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett. 2016 Jun;590(11):1576-85.