SB-590885

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TargetMol
Product Code: TAR-T2295
Supplier: TargetMol
CodeSizePrice
TAR-T2295-1mg1mg£99.00
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TAR-T2295-5mg5mg£139.00
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TAR-T2295-10mg10mg£177.00
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Quantity:
TAR-T2295-1mL1 mL * 10 mM (in DMSO)£189.00
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TAR-T2295-25mg25mg£286.00
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TAR-T2295-50mg50mg£483.00
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TAR-T2295-100mg100mg£670.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay). The selectivity of SB590885 for B-Raf is 11-fold greater over c-Raf, no acts to other human kinases.
CAS:
405554-55-4
Formula:
C27H27N5O2
Molecular Weight:
453.546
Pathway:
MAPK
Purity:
0.9848
SMILES:
CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc2C(CCc2c1)=N/O
Target:
Raf

References

1. King AJ, et al. Cancer Res, 2006, 66(23), 11100-11105. 2. Takle AK, et al. Bioorg Med Chem Lett, 2006, 16(2), 378-381. 3. Smalley KS, et al. Mol Cancer Ther, 2008, 7(9), 2876-2883.