Adechlorin
| Code | Size | Price |
|---|
| TAR-T23633-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Adechlorin is a synergistic antitumor and/or antiviral antibiotic. It potentiates the effects of other antitumor or antiviral compounds through the inhibition of key enzymes.
CAS:
96328-17-5
Formula:
C11H15ClN4O4
Molecular Weight:
302.72
Purity:
0.98
SMILES:
OC[C@H]1O[C@H]([C@H](Cl)[C@@H]1O)n1cnc2[C@H](O)CN=CNc12
References
1. Gao Y, Xu G, Wu P, Liu J, Cai YS, Deng Z, Chen W. Biosynthesis of 2'-Chloropentostatin and 2'-Amino-2'-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in Actinomadura sp. Strain ATCC 39365. Appl Environ Microbiol. 2017 May 1;83(10). pii: e00078-17. doi: 10.1128/AEM.00078-17. Print 2017 May 15. PubMed PMID: 28258148; PubMed Central PMCID: PMC5411499.
2. Hosmane RS. Ring-expanded ("Fat") nucleosides as broad-spectrum anticancer and antiviral agents. Curr Top Med Chem. 2002 Oct;2(10):1093-109. Review. PubMed PMID: 12173969.
3. Suhadolnik RJ, Pornbanlualap S, Baker DC, Tiwari KN, Hebbler AK. Stereospecific 2'-amination and 2'-chlorination of adenosine by Actinomadura in the biosynthesis of 2'-amino-2'-deoxyadenosine and 2'-chloro-2'-deoxycoformycin. Arch Biochem Biophys. 1989 Apr;270(1):374-82. PubMed PMID: 2784655.
4. Jackson RC, Leopold WR, Ross DA. The biochemical pharmacology of (2'-R)-chloropentostatin, a novel inhibitor of adenosine deaminase. Adv Enzyme Regul. 1986;25:125-39. PubMed PMID: 2433905.