AF-2785
Code | Size | Price |
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TAR-T23648-5mg | 5mg | £930.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T23648-50mg | 50mg | £1,821.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T23648-100mg | 100mg | £2,319.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.
CAS:
252025-48-2
Formula:
C17H12Cl2N2O2
Molecular Weight:
347.2
Purity:
0.98
SMILES:
OC(=O)C=Cc1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12
References
1. Gong XD, Linsdell P, Cheung KH, Leung GP, Wong PY. Indazole inhibition of cystic fibrosis transmembrane conductance regulator Cl(-) channels in rat epididymal epithelial cells. Biol Reprod. 2002 Dec;67(6):1888-96. PubMed PMID: 12444067.
2. Cheng CY, Mo My, Grima J, Saso L, Tita B, Mruk D, Silvestrini B. Indazole carboxylic acids in male contraception. Contraception. 2002 Apr;65(4):265-8. Review. PubMed PMID: 12020774.
3. Cheng CY, Silvestrini B, Grima J, Mo MY, Zhu LJ, Johansson E, Saso L, Leone MG, Palmery M, Mruk D. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biol Reprod. 2001 Aug;65(2):449-61. PubMed PMID: 11466213.
4. Gong XD, Wong PY. Characterization of Lonidamine and AF2785 blockade of the cyclic AMP-activated chloride current in rat epididymal cells. J Membr Biol. 2000 Dec 1;178(3):225-33. PubMed PMID: 11140278.