AFD-21
| Code | Size | Price |
|---|
| TAR-T23652-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T23652-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T23652-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
AFD-21 is a class I antiarrhythmic compound.
CAS:
99465-44-8
Formula:
C28H39NO5
Molecular Weight:
469.622
Purity:
0.98
SMILES:
OC(=O)C=C/C(O)=O.CC(C)CN(CCCC(O)(c1ccccc1)c1ccccc1)CC(C)C
References
1. Williams LK, Forero JF, Popovic ZB, Phelan D, Delgado D, Rakowski H, Wintersperger BJ, Thavendiranathan P. Patterns of CMR measured longitudinal strain and its association with late gadolinium enhancement in patients with cardiac amyloidosis and its mimics. J Cardiovasc Magn Reson. 2017 Aug 7;19(1):61. doi: 10.1186/s12968-017-0376-0. PubMed PMID: 28784140; PubMed Central PMCID: PMC5545847.
2. Komori S, Sawanobori T, Tamura K, Kane KA, Parratt JR. Effects of NS-2, a new class 1 antiarrhythmic agent, and AFD-19, its active metabolite, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: comparison with disopyramide and mexiletine. Jpn J Pharmacol. 1994 Jul;65(3):193-200. PubMed PMID: 7799519.
3. Kodama I, Kamiya K, Kawamura T, Suzuki R, Toyama J. Electrophysiological effects of AFD-21 and AFD-19, new antiarrhythmic compounds on papillary muscles and single ventricular myocytes isolated from guinea-pig hearts. Br J Pharmacol. 1990 Dec;101(4):803-8. PubMed PMID: 2085705; PubMed Central PMCID: PMC1917845.
4. Kojima M, Ban T. Effects of AFD-21, a new class I antiarrhythmic agent, and AFD-19, its active metabolite, on the maximal rate of rise of action potentials in guinea pig papillary muscles: dependence on time, voltage, and action potential duration. J Cardiovasc Pharmacol. 1989 Mar;13(3):483-93. PubMed PMID: 2471896.