Aladotrilat
| Code | Size | Price |
|---|
| TAR-T23699-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T23699-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T23699-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Aladotrilat is an inhibitor of neutral endopeptidase. Its prodrug is aladrotril.
CAS:
135038-59-4
Formula:
C14H17NO5S
Molecular Weight:
311.35
Purity:
0.98
SMILES:
C[C@H](NC(=O)[C@@H](CS)Cc1ccc2OCOc2c1)C(O)=O
References
1. Ul-Haq Z, Usmani S, Iqbal S, Zia SR. In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity. Mol Biosyst. 2016 Mar;12(3):1024-36. doi: 10.1039/c5mb00727e. PubMed PMID: 26846903.
2. Machowska A, Juszczak K, Novak P, Thor P. The natriuretic peptide neurohormonal system modulation by vasopeptidase inhibitors--the novel therapeutical approach of hypertension treatment. Folia Med Cracov. 2009;50(3-4):35-42. Review. PubMed PMID: 21853869.
3. Marie C, Mossiat C, Lecomte JM, Bralet J. Acute natriuretic effect of fasidotrilat, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in rats with heart failure. Pharmacology. 1998 Jun;56(6):291-6. PubMed PMID: 9654215.
4. Marie C, Mossiat C, Lecomte JM, Schwartz JC, Bralet J. Hemodynamic effects of acute and chronic treatment with aladotril, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in conscious rats with myocardial infarction. J Pharmacol Exp Ther. 1995 Dec;275(3):1324-31. PubMed PMID: 8531099.