AMDE-1

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TargetMol
Product Code: TAR-T23716
Supplier: TargetMol
CodeSizePrice
TAR-T23716-1mg1mg£227.00
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TAR-T23716-2mg2mg£306.00
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TAR-T23716-5mg5mg£431.00
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Quantity:
TAR-T23716-1mL1 mL * 10 mM (in DMSO)£470.00
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Quantity:
TAR-T23716-10mg10mg£600.00
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TAR-T23716-25mg25mg£863.00
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TAR-T23716-50mg50mg£1,187.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
AMDE-1 is an autophagy modulator and triggers autophagy in an Atg5-dependent manner. AMDE-1 recruits Atg16 to the pre-autophagosomal site and causes LC3 lipidation.
CAS:
478043-30-0
Formula:
C18H8ClF6N3
Molecular Weight:
415.72
Pathway:
Autophagy
Purity:
0.98
SMILES:
N#CC(C1=NC2=NC(=CC(=C2C=C1)C(F)(F)F)C(F)(F)F)C=3C=CC=C(Cl)C3
Target:
Autophagy

References

Gao Y, et al. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis. 2016 Aug 11;7(8):e2330. Li M, et al. AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One. 2015 Apr 20;10(3):e0122083.