Amicoumacin A
| Code | Size | Price |
|---|
| TAR-T23725-5mg | 5mg | £1,572.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T23725-50mg | 50mg | £3,107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T23725-100mg | 100mg | £4,247.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Amicoumacin A has antibacterial activity. It also strongly suppresses inflammatory and ulcer activity.
CAS:
78654-44-1
Formula:
C20H29N3O7
Molecular Weight:
423.466
Purity:
0.98
SMILES:
CC(C)CC(NC(=O)C(O)C(O)C(N)CC(N)=O)C1Cc2cccc(O)c2C(=O)O1
References
1. Gao XY, Liu Y, Miao LL, Li EW, Hou TT, Liu ZP. Mechanism of anti-Vibrio activity of marine probiotic strain Bacillus pumilus H2, and characterization of the active substance. AMB Express. 2017 Dec;7(1):23. doi: 10.1186/s13568-017-0323-3. Epub 2017 Jan 17. PubMed PMID: 28097594; PubMed Central PMCID: PMC5241254.
2. Prokhorova IV, Akulich KA, Makeeva DS, Osterman IA, Skvortsov DA, Sergiev PV, Dontsova OA, Yusupova G, Yusupov MM, Dmitriev SE. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome. Sci Rep. 2016 Jun 14;6:27720. doi: 10.1038/srep27720. PubMed PMID: 27296282; PubMed Central PMCID: PMC4906347.
3. Melnikov SV, S?ll D, Steitz TA, Polikanov YS. Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome. Nucleic Acids Res. 2016 Jun 2;44(10):4978-87. doi: 10.1093/nar/gkw246. Epub 2016 Apr 13. PubMed PMID: 27079977; PubMed Central PMCID: PMC4889946.
4. Jiang J, Seo H, Chow CS. Post-transcriptional Modifications Modulate rRNA Structure and Ligand Interactions. Acc Chem Res. 2016 May 17;49(5):893-901. doi: 10.1021/acs.accounts.6b00014. Epub 2016 Apr 11. PubMed PMID: 27064497.