TargetMol

AnCoA4

Product Code:
 
TAR-T23735
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23735-5mg5mg£930.00
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TAR-T23735-50mg50mg£1,821.00
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Quantity:
TAR-T23735-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
AnCoA4 is an inhibitor of the Orai1 channel. It acts by blocking calcium influx, reducing its interaction with STIM1, inhibiting T cell activation.
CAS:
24211-36-7
Formula:
C22H18O6
Molecular Weight:
378.38
Purity:
0.98
SMILES:
COc1cc2OCOc2cc1-c1coc2c3C=CC(C)(C)Oc3ccc2c1=O

References

1. Zhang B, Naik JS, Jernigan NL, Walker BR, Resta TC. Reduced membrane cholesterol after chronic hypoxia limits Orai1-mediated pulmonary endothelial Ca(2+) entry. Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H359-H369. doi: 10.1152/ajpheart.00540.2017. Epub 2017 Nov 3. PubMed PMID: 29101179; PubMed Central PMCID: PMC5867657. 2. Sadaghiani AM, Lee SM, Odegaard JI, Leveson-Gower DB, McPherson OM, Novick P, Kim MR, Koehler AN, Negrin R, Dolmetsch RE, Park CY. Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays. Chem Biol. 2014 Oct 23;21(10):1278-1292. doi: 10.1016/j.chembiol.2014.08.016. Epub 2014 Oct 9. PubMed PMID: 25308275.