BRP-7
Code | Size | Price |
---|
TAR-T23824-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T23824-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T23824-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
BRP-7 is an inhibitor of 5-LO activating protein.
CAS:
612046-20-5
Formula:
C29H25ClN2O
Molecular Weight:
452.98
Purity:
0.98
SMILES:
CC(c1nc2ccccc2n1Cc1ccccc1Cl)c1ccc(OCc2ccccc2)cc1
References
1. Levent S, Gerstmeier J, Olga? A, Nikels F, Garscha U, Carotti A, Macchiarulo A, Werz O, Banoglu E, ?al??kan B. Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. Eur J Med Chem. 2016 Oct 21;122:510-519. doi: 10.1016/j.ejmech.2016.07.004. Epub 2016 Jul 5. PubMed PMID: 27423639.
2. Pergola C, Gerstmeier J, M?nch B, ?al??kan B, Luderer S, Weinigel C, Barz D, Maczewsky J, Pace S, Rossi A, Sautebin L, Banoglu E, Werz O. The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP). Br J Pharmacol. 2014 Jun;171(12):3051-64. doi: 10.1111/bph.12625. PubMed PMID: 24641614; PubMed Central PMCID: PMC4055205.