Coformycin
| Code | Size | Price |
|---|
| TAR-T23905-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Coformycin is a ribonucleoside antibiotic synergist and adenosine deaminase inhibitor.
CAS:
11033-22-0
Formula:
C11H16N4O5
Molecular Weight:
284.272
Purity:
0.98
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2[C@H](O)CN=CNc12
References
1. Bzowska A, Lassota P, Shugar D. Phosphorylation of coformycin and 2'-deoxycoformycin, and substrate and inhibitor properties of the nucleosides and nucleotides in several enzyme systems. Z Naturforsch C. 1985 Sep-Oct;40(9-10):710-4. PubMed PMID: 3002059.
2. Hanvey JC, Hawkins ES, Baker DC, Suhadolnik RJ. 8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2'-deoxycoformycin and coformycin. Biochemistry. 1988 Jul 26;27(15):5790-5. PubMed PMID: 3052586.
3. Danton MJ, Coleman MS. Isolation of mutant adenosine deaminase by coformycin affinity chromatography. Anal Biochem. 1986 Nov 15;159(1):233-9. PubMed PMID: 3492941.
4. Han BW, Bingman CA, Mahnke DK, Sabina RL, Phillips GN Jr. Crystallization and preliminary X-ray crystallographic analysis of adenosine 5'-monophosphate deaminase (AMPD) from Arabidopsis thaliana in complex with coformycin 5'-phosphate. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Aug 1;61(Pt 8):740-2. Epub 2005 Jul 8. PubMed PMID: 16511144; PubMed Central PMCID: PMC1952363.