DB772
| Code | Size | Price |
|---|
| TAR-T23966-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T23966-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T23966-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
DB772 is a scrapie prion accumulation inhibitor.
CAS:
1451058-50-6
Formula:
C20H16N4O
Molecular Weight:
328.375
Purity:
0.98
SMILES:
C1CN=C(N1)c1ccc(cc1)-c1ccc(o1)-c1nc2ccccc2[nH]1
References
1. Dinkel KD, Stanton JB, Boykin DW, Stephens CE, Madsen-Bouterse SA, Schneider DA. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5467-82. doi: 10.1128/AAC.00811-16. Print 2016 Sep. PubMed PMID: 27381401; PubMed Central PMCID: PMC4997874.
2. Newcomer BW, Marley MS, Galik PK, Zhang Y, Riddell KP, Boykin DW, Kumar A, Kuhnt LA, Gard JA, Givens MD. Effect of treatment with a cationic antiviral compound on acute infection with bovine viral diarrhea virus. Can J Vet Res. 2013 Jul;77(3):170-6. PubMed PMID: 24101792; PubMed Central PMCID: PMC3700441.
3. Newcomer BW, Neill JD, Marley MS, Ridpath JF, Givens MD. Mutations induced in the NS5B gene of bovine viral diarrhea virus by antiviral treatment convey resistance to the compound. Virus Res. 2013 Jun;174(1-2):95-100. doi: 10.1016/j.virusres.2013.03.007. Epub 2013 Mar 21. PubMed PMID: 23524138.
4. Stanton JB, Schneider DA, Dinkel KD, Balmer BF, Baszler TV, Mathison BA, Boykin DW, Kumar A. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173. doi: 10.1371/journal.pone.0051173. Epub 2012 Nov 30. Erratum in: PLoS One. 2015;10(3):e0119084. PubMed PMID: 23226483; PubMed Central PMCID: PMC3511409.