Deacylcortivazol
| Code | Size | Price |
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| TAR-T23975-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Deacylcortivazol (DAC) is a potent glucocorticoid. When incubated with glucocorticoid-resistant mutants derived from the glucocorticoid-sensitive human leukemic cell line CEM-C7, DAC caused significant growth inhibition. The cytotoxicity of DAC at concentrations higher than necessary for glucocorticoid receptor saturation is not mediated by glucocorticoid receptors.
CAS:
4906-84-7
Formula:
C30H36N2O4
Molecular Weight:
488.628
Purity:
0.98
SMILES:
C[C@@H]1C[C@H]2[C@@H]3C=C(C)C4=Cc5c(C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO)cnn5-c1ccccc1
References
1. Suino-Powell K, Xu Y, Zhang C, Tao YG, Tolbert WD, Simons SS Jr, Xu HE. Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol. Mol Cell Biol. 2008 Mar;28(6):1915-23. Epub 2007 Dec 26. PubMed PMID: 18160712; PubMed Central PMCID: PMC2268401.
2. Mrigank, Kothekar V. Computer stimulation of interaction of deacylcortivazol with d(TGTTCT)2. J Theor Biol. 1993 Jul 7;163(1):33-50. PubMed PMID: 8412241.
3. Harmon JM, Schmidt TJ, Thompson EB. Deacylcortivazol acts through glucocorticoid receptors. J Steroid Biochem. 1981 Mar;14(3):273-9. PubMed PMID: 6111624.
4. Harmon JM, Schmidt TJ, Thompson EB. Non-glucocorticoid receptor-mediated effects of the potent glucocorticoid deacylcortivazol. Cancer Res. 1982 Jun;42(6):2110-4. PubMed PMID: 6951631.