E 5090
| Code | Size | Price |
|---|
| TAR-T24022-5mg | 5mg | £1,653.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24022-50mg | 50mg | £3,267.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24022-100mg | 100mg | £4,488.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
E5090 is a novel orally active inhibitor of IL-1 generation. It also has anti-inflammatory properties.
CAS:
131420-91-2
Formula:
C19H20O5
Molecular Weight:
328.364
Purity:
0.98
SMILES:
CCc1cccc2c(C=C(C)C(O)=O)cc(OC)c(OC(C)=O)c12
References
1. Fukumura D, Miura S, Kurose I, Higuchi H, Suzuki H, Ebinuma H, Han JY, Watanabe N, Wakabayashi G, Kitajima M, Ishii H. IL-1 is an important mediator for microcirculatory changes in endotoxin-induced intestinal mucosal damage. Dig Dis Sci. 1996 Dec;41(12):2482-92. PubMed PMID: 9011462.
2. Tanaka M, Chiba K, Okita M, Kaneko T, Tagami K, Hibi S, Okamoto Y, Shirota H, Goto M, Obaishi H, et al. A novel orally active inhibitor of IL-1 generation: synthesis and structure-activity relationships of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acid derivatives. J Med Chem. 1992 Dec 11;35(25):4665-75. PubMed PMID: 1469696.
3. Chiba K, Goto M, Shirota H. A novel inhibitor of IL-1 generation, E5090: in vivo inhibitory effect on the generation of IL-1-like factor and on granuloma formation in an air-pouch model. Agents Actions Suppl. 1991;32:231-5. PubMed PMID: 2069092.
4. Goto M, Chiba K, Hashida R, Shirota H. A novel inhibitor of IL-1 generation, E5090: in vitro inhibitory effects on the generation of IL-1 by human monocytes. Agents Actions Suppl. 1991;32:225-9. PubMed PMID: 2069091.