EM20-25
| Code | Size | Price |
|---|
| TAR-T24027-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24027-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24027-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
EM20-25 is a novel BCL-2 inhibitor. It also neutralizes the antiapoptotic activity of overexpressed BCL-2 toward staurosporine.
CAS:
141266-44-6
Formula:
C15H9ClN4O6
Molecular Weight:
376.71
Purity:
0.98
SMILES:
Clc1ccc2Oc3[nH]c(=O)[nH]c(=O)c3C(C3C(=O)NC(=O)NC3=O)c2c1
References
1. Vasaikar SV, Ghosh S, Narain P, Basu A, Gomes J. HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation. Front Cell Neurosci. 2015 Aug 25;9:319. doi: 10.3389/fncel.2015.00319. eCollection 2015. PubMed PMID: 26379495; PubMed Central PMCID: PMC4548197.
2. Ciscato F, Sciacovelli M, Villano G, Turato C, Bernardi P, Rasola A, Pontisso P. SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I. Oncotarget. 2014 May 15;5(9):2418-27. PubMed PMID: 24810714; PubMed Central PMCID: PMC4058015.
3. Buron N, Porceddu M, Brabant M, Desgu? D, Racoeur C, Lassalle M, P?choux C, Rustin P, Jacotot E, Borgne-Sanchez A. Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization. PLoS One. 2010 Mar 31;5(3):e9924. doi: 10.1371/journal.pone.0009924. PubMed PMID: 20360986; PubMed Central PMCID: PMC2847598.
4. Rasola A, Sciacovelli M, Chiara F, Pantic B, Brusilow WS, Bernardi P. Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):726-31. doi: 10.1073/pnas.0912742107. Epub 2009 Dec 22. PubMed PMID: 20080742; PubMed Central PMCID: PMC2818893.