F-amidine
| Code | Size | Price |
|---|
| TAR-T24054-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24054-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24054-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
F-amidine is a bioavailable irreversible PAD4 inactivator.
CAS:
877617-45-3
Formula:
C14H19FN4O2
Molecular Weight:
294.33
Purity:
0.98
SMILES:
NC(=O)[C@H](CCCN=C(/N)CF)NC(=O)c1ccccc1
References
1. Wei Y, Liu R, Liu C, Jin J, Li D, Lin J. Identification of novel PAD4 inhibitors based on a pharmacophore model derived from transition state coordinates. J Mol Graph Model. 2017 Mar;72:88-95. doi: 10.1016/j.jmgm.2016.11.016. Epub 2016 Dec 19. PubMed PMID: 28064083.
2. Li D, Liu C, Lin J. Theoretical study of the mechanism of protein arginine deiminase 4 (PAD4) inhibition by F-amidine. J Mol Graph Model. 2015 Feb;55:25-32. doi: 10.1016/j.jmgm.2014.10.014. Epub 2014 Nov 7. PubMed PMID: 25424656.
3. Bicker KL, Anguish L, Chumanevich AA, Cameron MD, Cui X, Witalison E, Subramanian V, Zhang X, Chumanevich AP, Hofseth LJ, Coonrod SA, Thompson PR. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085. PubMed PMID: 23420624; PubMed Central PMCID: PMC3572853.
4. Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol. 2012 Jan 20;7(1):160-5. doi: 10.1021/cb200258q. Epub 2011 Oct 21. PubMed PMID: 22004374; PubMed Central PMCID: PMC3262960.