FzM1

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TargetMol
Product Code: TAR-T24076
Supplier: TargetMol
CodeSizePrice
TAR-T24076-1mg1mg£99.00
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Quantity:
TAR-T24076-1mL1 mL * 10 mM (in DMSO)£115.00
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Quantity:
TAR-T24076-5mg5mg£128.00
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Quantity:
TAR-T24076-10mg10mg£158.00
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Quantity:
TAR-T24076-25mg25mg£230.00
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Quantity:
TAR-T24076-50mg50mg£369.00
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Quantity:
TAR-T24076-100mg100mg£517.00
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TAR-T24076-500mg500mg£1,050.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
FzM1 is the first allosteric ligand of Frizzled4 that acts by specifically signaling downstream of Wnt5a to promote dendrite branching and growth.
CAS:
1680196-54-6
Formula:
C21H16N2O2S
Molecular Weight:
360.43
Pathway:
Stem Cells|Cytoskeletal Signaling
Purity:
0.98
SMILES:
Oc1cc(NC(=O)Nc2ccc3ccccc3c2)cc(c1)-c1cccs1
Target:
Wnt/beta-catenin

References

Riccio G, et al. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851. Generoso SF, et al. Pharmacological folding chaperones act as allosteric ligands of Frizzled4. Nat Chem Biol. 2015 Apr;11(4):280-6.