Gamendazole
| Code | Size | Price |
|---|
| TAR-T24084-5mg | 5mg | £930.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24084-50mg | 50mg | £1,821.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24084-100mg | 100mg | £2,319.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Gamendazole is a novel drug candidate for male contraception. It has been shown to reduce fertility in male rats without affecting testosterone levels.
CAS:
877773-32-5
Formula:
C18H11Cl2F3N2O2
Molecular Weight:
415.19
Purity:
0.98
SMILES:
OC(=O)C=Cc1nn(Cc2ccc(Cl)cc2Cl)c2cc(ccc12)C(F)(F)F
References
1. Burglov? K, Rylov? G, Markos A, Prichystalova H, Soural M, Petracek M, Medvedikova M, Tejral G, Sopko B, Hradil P, Dzubak P, Hajduch M, Hlavac J. Identification of Eukaryotic Translation Elongation Factor 1-? 1 Gamendazole-Binding Site for Binding of 3-Hydroxy-4(1 H)-quinolinones as Novel Ligands with Anticancer Activity. J Med Chem. 2018 Mar 16. doi: 10.1021/acs.jmedchem.8b00078. [Epub ahead of print] PubMed PMID: 29498519.
2. Naas M, El Kazzouli S, Essassi el M, Bousmina M, Guillaumet G. Palladium-Catalyzed Oxidative Direct C3- and C7-Alkenylations of Indazoles: Application to the Synthesis of Gamendazole. Org Lett. 2015 Sep 4;17(17):4320-3. doi: 10.1021/acs.orglett.5b02136. Epub 2015 Aug 26. PubMed PMID: 26308587.
3. Olesen SH, Ingles DJ, Zhu JY, Martin MP, Betzi S, Georg GI, Tash JS, Sch?nbrunn E. Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2. Molecules. 2015 Jan 19;20(1):1643-60. doi: 10.3390/molecules20011643. PubMed PMID: 25608045; PubMed Central PMCID: PMC4601640.
4. Cheng CY. Toxicants target cell junctions in the testis: Insights from the indazole-carboxylic acid model. Spermatogenesis. 2015 Jan 21;4(2):e981485. eCollection 2014 May-Aug. Review. PubMed PMID: 26413399; PubMed Central PMCID: PMC4581065.