GP29
| Code | Size | Price |
|---|
| TAR-T24099-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24099-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24099-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
GP29 is a Type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.
CAS:
1415050-59-7
Formula:
C33H28F3N5O3
Molecular Weight:
599.614
Purity:
0.98
SMILES:
CC(=O)NCCOc1ccc(Nc2ncc3cc(ccc3n2)-c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
References
1. Mehla J, Dedrick RM, Caufield JH, Wagemans J, Sakhawalkar N, Johnson A, Hatfull GF, Uetz P. Virus-host protein-protein interactions of mycobacteriophage Giles. Sci Rep. 2017 Nov 28;7(1):16514. doi: 10.1038/s41598-017-16303-7. PubMed PMID: 29184079; PubMed Central PMCID: PMC5705681.
2. Hu B, Margolin W, Molineux IJ, Liu J. Structural remodeling of bacteriophage T4 and host membranes during infection initiation. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4919-28. doi: 10.1073/pnas.1501064112. Epub 2015 Aug 17. PubMed PMID: 26283379; PubMed Central PMCID: PMC4568249.
3. Paul J, Naskar K, Chowdhury S, Alam MN, Chakraborti T, De T. TLR4-mediated activation of MyD88 signaling induces protective immune response and IL-10 down-regulation in Leishmania donovani infection. Indian J Biochem Biophys. 2014 Dec;51(6):531-41. PubMed PMID: 25823227.
4. Paul J, Naskar K, Chowdhury S, Chakraborti T, De T. TLR mediated GSK3? activation suppresses CREB mediated IL-10 production to induce a protective immune response against murine visceral leishmaniasis. Biochimie. 2014 Dec;107 Pt B:235-46. doi: 10.1016/j.biochi.2014.09.004. Epub 2014 Sep 16. PubMed PMID: 25223889.