GSK854
Code | Size | Price |
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TAR-T24115-5mg | 5mg | £270.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24115-50mg | 50mg | £1,026.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24115-100mg | 100mg | £1,564.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
GSK854 is an effective TNNI3K inhibitor (IC50 < 10 nM). GSK854 shows substantial selectivity against B-Raf (>25-fold) and EGFR (IC50 > 25 μM). It also shows excellent broad-spectrum kinase selectivity with >100-fold selectivity over 96% of kinases tested.
CAS:
1316059-00-3
Formula:
C18H19ClN6O4S2
Molecular Weight:
482.96
Purity:
0.98
SMILES:
CCS(=O)(=O)c1ccc(cc1Nc1cc(Nc2ccc(Cl)cn2)ncn1)S(=O)(=O)NC
References
1. 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors Joanne Philp, Brian G. Lawhorn, Alan P. Graves, Lisa Shewchuk, Katrina L. Rivera, Larry J. Jolivette, Dennis A. Holt, Gregory J. Gatto Jr. and Lara S. Kallander Publication Date (Web): March 21, 2018 (Article) doi: 10.1021/acs.jmedchem.8b00125