GW8510
| Code | Size | Price |
|---|
| TAR-T24125-50mg | 50mg | £870.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24125-100mg | 100mg | £1,267.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
GW8510 is a cyclin kinase 2 inhibitor.
CAS:
222036-17-1
Formula:
C21H15N5O3S2
Molecular Weight:
449.5
Purity:
0.98
SMILES:
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(cc1)S(=O)(=O)Nc1ccccn1
References
1. Chen P, Wu JN, Shu Y, Jiang HG, Zhao XH, Qian H, Chen K, Lan T, Chen CG, Li J. Gemcitabine resistance mediated by ribonucleotide reductase M2 in lung squamous cell carcinoma is reversed by GW8510 through autophagy induction. Clin Sci (Lond). 2018 May 31. pii: CS20180010. doi: 10.1042/CS20180010. [Epub ahead of print] PubMed PMID: 29853661.
2. Guyett PJ, Xia S, Swinney DC, Pollastri MP, Mensa-Wilmot K. Glycogen Synthase Kinase 3? Promotes the Endocytosis of Transferrin in the African Trypanosome. ACS Infect Dis. 2016 Jul 8;2(7):518-28. doi: 10.1021/acsinfecdis.6b00077. Epub 2016 Jun 16. PubMed PMID: 27626104; PubMed Central PMCID: PMC5025259.
3. Hsieh YY, Chou CJ, Lo HL, Yang PM. Repositioning of a cyclin-dependent kinase inhibitor GW8510 as a ribonucleotide reductase M2 inhibitor to treat human colorectal cancer. Cell Death Discov. 2016 May 9;2:16027. doi: 10.1038/cddiscovery.2016.27. eCollection 2016. PubMed PMID: 27551518; PubMed Central PMCID: PMC4979501.
4. Wimalasena NK, Le VQ, Wimalasena K, Schreiber SL, Karmacharya R. Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent. ACS Chem Neurosci. 2016 Jul 20;7(7):857-63. doi: 10.1021/acschemneuro.6b00076. Epub 2016 Jun 9. PubMed PMID: 27270122.