H2-005

TargetMol
Product Code: TAR-T24128
Supplier: TargetMol
CodeSizePrice
TAR-T24128-5mg5mg£850.00
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Quantity:
TAR-T24128-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24128-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
CAS:
1060478-12-7
Formula:
C24H32N4O4
Molecular Weight:
440.544
Purity:
0.98
SMILES:
CCC(CC)Nc1cnc2n(CCC(C)C)c(C(=O)OC)c(NC(=O)c3ccco3)c2c1

References

1. Shortell SM, Addicott R, Walsh N, Ham C. The NHS five year forward view: lessons from the United States in developing new care models. BMJ. 2015 Apr 21;350:h2005. doi: 10.1136/bmj.h2005. PubMed PMID: 25899794. 2. Martinez-Lemus LA, Zhao G, Gali?anes EL, Boone M. Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases. Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2005-15. doi: 10.1152/ajpheart.01066.2010. Epub 2011 Apr 1. PubMed PMID: 21460197; PubMed Central PMCID: PMC3119084. 3. Wang Y, Chen AF, Wang DH. ET(A) receptor blockade prevents renal dysfunction in salt-sensitive hypertension induced by sensory denervation. Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2005-11. Epub 2005 Jul 1. PubMed PMID: 15994858. 4. Song Y, Belardinelli L. ATP promotes development of afterdepolarizations and triggered activity in cardiac myocytes. Am J Physiol. 1994 Nov;267(5 Pt 2):H2005-11. PubMed PMID: 7526716.