Hoe 140, desarg(10)-
| Code | Size | Price |
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| TAR-T24147-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Hoe 140 is an effective antagonist of B1 bradykinin.
CAS:
138680-92-9
Formula:
C53H77N15O12S
Molecular Weight:
1148.35
Purity:
0.98
SMILES:
N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)C1CCC[C@@H]2N[C@](C(C(=O)c3nccc4CCCCc34)[C@@]12C(=O)CNC(=O)[C@@H]1CC(O)CN1)(C(O)=O)C(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cccs1
References
1. Bujalska-Zadro?ny M, de Cord? A, Cegielska-Perun K, G?si?ska E, Makulska-Nowak H. Dose-depending effect of intracerebroventricularly administered bradykinin on nociception in rats. Pharmacol Rep. 2013;65(4):1006-11. PubMed PMID: 24145095.
2. Lim SK, Park SH. The high glucose-induced stimulation of B1R and B2R expression via CB(1)R activation is involved in rat podocyte apoptosis. Life Sci. 2012 Nov 2;91(19-20):895-906. doi: 10.1016/j.lfs.2012.07.020. Epub 2012 Jul 31. PubMed PMID: 22877648.
3. Meini S, Cucchi P, Catalani C, Bellucci F, Giuliani S, Maggi CA. Bradykinin and B? receptor antagonism in rat and human articular chondrocytes. Br J Pharmacol. 2011 Feb;162(3):611-22. doi: 10.1111/j.1476-5381.2010.01062.x. PubMed PMID: 20946124; PubMed Central PMCID: PMC3041251.
4. Meini S, Cucchi P, Catalani C, Bellucci F, Santicioli P, Giuliani S, Maggi CA. Radioligand binding characterization of the bradykinin B(2) receptor in the rabbit and pig ileal smooth muscle. Eur J Pharmacol. 2010 Jun 10;635(1-3):34-9. doi: 10.1016/j.ejphar.2010.03.012. Epub 2010 Mar 20. PubMed PMID: 20307535.