HR22C16
| Code | Size | Price |
|---|
| TAR-T24150-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24150-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24150-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.
CAS:
462630-41-7
Formula:
C23H23N3O3
Molecular Weight:
389.455
Purity:
0.98
SMILES:
CCCCN1C(=O)C2Cc3c([nH]c4ccccc34)C(N2C1=O)c1cccc(O)c1
References
1. Shankaraiah N, Nekkanti S, Chudasama KJ, Senwar KR, Sharma P, Jeengar MK, Naidu VG, Srinivasulu V, Srinivasulu G, Kamal A. Design, synthesis and anticancer evaluation of tetrahydro-?-carboline-hydantoin hybrids. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5413-7. PubMed PMID: 25453799.
2. Liu F, Yu LQ, Jiang C, Yang L, Wu WT, You QD. Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. Bioorg Med Chem. 2010 Jun 15;18(12):4167-77. doi: 10.1016/j.bmc.2010.05.024. Epub 2010 May 11. PubMed PMID: 20537544.
3. Jiang C, Chen Y, Wang X, You Q. Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly. J Mol Model. 2007 Sep;13(9):987-92. Epub 2007 Jun 23. PubMed PMID: 17588180.
4. Dastidar PG, Majumder S, Lohia A. Eh Klp5 is a divergent member of the kinesin 5 family that regulates genome content and microtubular assembly in Entamoeba histolytica. Cell Microbiol. 2007 Feb;9(2):316-28. Epub 2006 Aug 22. PubMed PMID: 16925786.