HS-72
| Code | Size | Price |
|---|
| TAR-T24151-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24151-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24151-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
HS-72 is an allosteric inhibitor. It is also selective for the inducible form of Hsp70.
CAS:
1118861-60-1
Formula:
C20H24N6O
Molecular Weight:
364.453
Purity:
0.98
SMILES:
CCCn1c(NC(=O)[C@H]2CCCN(C2)c2cnccn2)nc2ccccc12
References
1. Hagiya K, Hayasaka K, Yamazaki T, Shirai T, Osawa T, Terawaki Y, Nagamine Y, Masuda Y, Suzuki M. Effects of heat stress on production, somatic cell score and conception rate in Holsteins. Anim Sci J. 2017 Jan;88(1):3-10. doi: 10.1111/asj.12617. Epub 2016 Apr 25. PubMed PMID: 27113198.
2. Howe MK, Speer BL, Hughes PF, Loiselle DR, Vasudevan S, Haystead TA. An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. Antiviral Res. 2016 Jun;130:81-92. doi: 10.1016/j.antiviral.2016.03.017. Epub 2016 Apr 4. PubMed PMID: 27058774; PubMed Central PMCID: PMC4955699.
3. Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, Haystead TA. Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chem Biol. 2014 Dec 18;21(12):1648-59. doi: 10.1016/j.chembiol.2014.10.016. Epub 2014 Dec 11. PubMed PMID: 25500222; PubMed Central PMCID: PMC4272656.
4. Fujii S, Okinaga T, Ariyoshi W, Takahashi O, Iwanaga K, Nishino N, Tominaga K, Nishihara T. Mechanisms of G1 cell cycle arrest and apoptosis in myeloma cells induced by hybrid-compound histone deacetylase inhibitor. Biochem Biophys Res Commun. 2013 May 10;434(3):413-20. doi: 10.1016/j.bbrc.2013.03.043. Epub 2013 Mar 26. PubMed PMID: 23537658.