IT-9302
| Code | Size | Price |
|---|
| TAR-T24183-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
IT-9302 is a synthetic agonist of interleukin-10.
CAS:
173959-12-1
Formula:
C48H82N14O13S2
Molecular Weight:
1127.39
Purity:
0.98
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
References
1. L?pez MN, Pesce B, Kurte M, P?rez C, Segal G, Roa J, Aguill?n JC, Mendoza-Naranjo A, Gesser B, Larsen C, Villablanca A, Choudhury A, Kiessling R, Salazar-Onfray F. A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-?+ tolerogenic dendritic cells. Immunobiology. 2011 Oct;216(10):1117-26. doi: 10.1016/j.imbio.2011.04.006. Epub 2011 Apr 22. PubMed PMID: 21601308.
2. Salazar-Onfray F, L?pez MN, Mendoza-Naranjo A. Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Factor Rev. 2007 Feb-Apr;18(1-2):171-82. Epub 2007 Feb 27. Review. PubMed PMID: 17329145.
3. Kurte M, L?pez M, Aguirre A, Escobar A, Aguill?n JC, Charo J, Larsen CG, Kiessling R, Salazar-Onfray F. A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and Transporter associated with Antigen Processing 1/2 in human melanoma cells. J Immunol. 2004 Aug 1;173(3):1731-7. PubMed PMID: 15265902.
4. Osman MO, Gesser B, Mortensen JT, Matsushima K, Jensen SL, Larsen CG. Profiles of pro-inflammatory cytokines in the serum of rabbits after experimentally induced acute pancreatitis. Cytokine. 2002 Jan 7;17(1):53-9. PubMed PMID: 11886171.