Jmv 179
| Code | Size | Price |
|---|
| TAR-T24204-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Jmv 179 is an antagonist of the cholecystokinin receptor.
CAS:
119386-87-7
Formula:
C51H67N7O15S
Molecular Weight:
1050.19
Purity:
0.98
SMILES:
CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)OCCc1ccccc1
References
1. Quesada A, Micevych P. Estrogen and CCK1 receptor modification of mu-opioid receptor binding in the cortex of female rats. Brain Res. 2006 Feb 16;1073-1074:316-20. Epub 2006 Feb 10. PubMed PMID: 16472782.
2. Gigoux V, Escrieut C, Fehrentz JA, Poirot S, Maigret B, Moroder L, Gully D, Martinez J, Vaysse N, Fourmy D. Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin. J Biol Chem. 1999 Jul 16;274(29):20457-64. PubMed PMID: 10400673.
3. Kennedy K, Gigoux V, Escrieut C, Maigret B, Martinez J, Moroder L, Fr?hel D, Gully D, Vaysse N, Fourmy D. Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin. J Biol Chem. 1997 Jan 31;272(5):2920-6. PubMed PMID: 9006937.
4. Camby I, Salmon I, Oiry C, Galleyrand JC, Nagy N, Danguy A, Brotchi J, Pasteels JL, Martinez J, Kiss R. The influence of gastrin and/or cholecystokinin antagonists on the proliferation of three human astrocytic tumor cell lines. Neuropeptides. 1996 Oct;30(5):433-7. PubMed PMID: 8923504.