JS-K
| Code | Size | Price |
|---|
| TAR-T24215-5mg | 5mg | £381.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24215-50mg | 50mg | £1,291.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24215-100mg | 100mg | £1,910.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
JS-K is a Nitric oxide donor. It has antiproliferative activity.
CAS:
205432-12-8
Formula:
C13H16N6O8
Molecular Weight:
384.305
Purity:
0.98
SMILES:
CCOC(=O)N1CCN(CC1)[N+]([O-])=NOc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
References
1. Liu L, Huang Z, Chen J, Wang J, Wang S. Protein phosphatase 2A mediates JS-K-induced apoptosis by affecting Bcl-2 family proteins in human hepatocellular carcinoma HepG2 cells. J Cell Biochem. 2018 Apr 25. doi: 10.1002/jcb.26845. [Epub ahead of print] PubMed PMID: 29693750.
2. Kang F, Ai Y, Zhang Y, Huang Z. Design and synthesis of new hybrids from 2-cyano-3,12-dioxooleana- 9-dien-28-oic acid and O(2)-(2,4-dinitrophenyl) diazeniumdiolate for intervention of drug-resistant lung cancer. Eur J Med Chem. 2018 Apr 10;149:269-280. doi: 10.1016/j.ejmech.2018.02.062. Epub 2018 Feb 23. PubMed PMID: 29501947.
3. Huang Z, Wu J, Zou Y, Yuan H, Zhang Y, Fei Y, Bhardwaj A, Kaur J, Knaus EE, Zhang Y. Glutathione S-Transferase ?-Activatable O(2)-(Sulfonylethyl Derived) Diazeniumdiolates Potently Suppress Melanoma in Vitro and in Vivo. J Med Chem. 2018 Mar 8;61(5):1833-1844. doi: 10.1021/acs.jmedchem.7b01178. Epub 2018 Feb 16. PubMed PMID: 29420887.
4. Li Q, Zou P, Sun J, Chen L. O(2)-(2,4-dinitrophenyl)diazeniumdiolates derivatives: Design, synthesis, cytotoxic evaluation and reversing MDR in MCF-7/ADR cells. Eur J Med Chem. 2018 Jan 1;143:732-744. doi: 10.1016/j.ejmech.2017.11.081. PubMed PMID: 29220794.