KL-1156
| Code | Size | Price |
|---|
| TAR-T24262-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
KL-1156 is an NF-κB inhibitor. It is also a lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.
CAS:
819868-62-7
Formula:
C17H17NO4
Molecular Weight:
299.326
Purity:
0.98
SMILES:
COc1cc2OC(CCc2cc1O)C(=O)Nc1ccccc1
References
1. Choi M, Jo H, Park HJ, Sateesh Kumar A, Lee J, Yun J, Kim Y, Han SB, Jung JK, Cho J, Lee K, Kwak JH, Lee H. Design, synthesis, and biological evaluation of benzofuran- and 2,3-dihydrobenzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives as anticancer agents and inhibitors of NF-?B. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2545-9. doi: 10.1016/j.bmcl.2015.04.050. Epub 2015 Apr 23. PubMed PMID: 25953156.
2. Choi M, Hwang YS, Kumar AS, Jo H, Jeong Y, Oh Y, Lee J, Yun J, Kim Y, Han SB, Jung JK, Cho J, Lee H. Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-?B inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2404-7. doi: 10.1016/j.bmcl.2014.04.053. Epub 2014 Apr 20. PubMed PMID: 24792464.
3. Kwak JH, Won SW, Kim TJ, Yi W, Choi EH, Kim SC, Park H, Roh E, Jung JK, Hwang BY, Hong JT, Kim Y, Cho J, Lee H. Synthesis and nuclear factor-kappaB inhibitory activities of 6- or 7-methylchroman-2-carboxylic acid N-(substituted) phenylamides. Arch Pharm Res. 2009 Feb;32(2):167-75. doi: 10.1007/s12272-009-1131-3. Epub 2009 Mar 13. PubMed PMID: 19280144.
4. Kwak JH, Won SW, Kim TJ, Roh E, Kang HY, Lee HW, Jung JK, Hwang BY, Kim Y, Cho J, Lee H. Synthesis of chroman-2-carboxylic acid N-(substituted)phenylamides and their inhibitory effect on nuclear factor-kappaB (NF-kappaB) activation. Arch Pharm Res. 2008 Feb;31(2):133-41. PubMed PMID: 18365680.