TargetMol

L 699333

Product Code:
 
TAR-T24345
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24345-5mg5mg£1,171.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24345-50mg50mg£2,303.00
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Quantity:
TAR-T24345-100mg100mg£3,042.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
L 699333 is an effective inhibitor of 5-lipoxygenase.
CAS:
155238-60-1
Formula:
C36H35ClN2O4S
Molecular Weight:
627.2
Purity:
0.98
SMILES:
CC[C@@H](OCCc1c2S[C@@H](C)Cc3c(OCc4ccc(cn4)-c4ccccc4)ccc(n1Cc1ccc(Cl)cc1)c23)C(O)=O

References

1. Gupta N, Greeser MJ, Ford-Hutchinson AW. A random rapid equilibrium mechanism for leukotriene C4 synthase. Adv Exp Med Biol. 1999;469:327-32. PubMed PMID: 10667349. 2. Gupta N, Gresser MJ, Ford-Hutchinson AW. Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase. Biochim Biophys Acta. 1998 Mar 30;1391(2):157-68. PubMed PMID: 9554994. 3. Negro JM, Miralles JC, Ortiz JL, Funes E, Garc?a A. Biosynthesis inhibitors for leukotrienes in bronchial asthma. Allergol Immunopathol (Madr). 1997 Jul-Aug;25(4):209-16. Review. PubMed PMID: 9269512. 4. Hutchinson JH, Riendeau D, Brideau C, Chan C, Falgueyret JP, Guay J, Jones TR, L?pine C, Macdonald D, McFarlane CS, et al. Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. J Med Chem. 1994 Apr 15;37(8):1153-64. PubMed PMID: 8164257.