L 739749
| Code | Size | Price |
|---|
| TAR-T24356-5mg | 5mg | £1,492.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24356-50mg | 50mg | £2,946.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24356-100mg | 100mg | £4,006.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
L 739749 is a CAAX peptidomimetic. It is also an inhibitor of farnesyl-protein transferase.
CAS:
156511-34-1
Formula:
C24H41N3O6S2
Molecular Weight:
531.73
Purity:
0.98
SMILES:
CC[C@H](C)CCON(C(=O)CCc1ccccc1)[C@@](CCS(C)(=O)=O)(NCC(N)CS)C(=O)OC
References
1. Dazy S, Damiola F, Parisey N, Beug H, Gandrillon O. The MEK-1/ERKs signalling pathway is differentially involved in the self-renewal of early and late avian erythroid progenitor cells. Oncogene. 2003 Dec 18;22(58):9205-16. PubMed PMID: 14681680.
2. Xu Y, Chiamvimonvat N, V?zquez AE, Akunuru S, Ratner N, Yamoah EN. Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. J Neurosci. 2002 Nov 1;22(21):9194-202. PubMed PMID: 12417644.
3. Bulus NM, Sheng HM, Sizemore N, Oldham SM, Barnett JV, Coffey RJ, Beauchamp DR, Barnard JA. Ras-mediated suppression of TGFbetaRII expression in intestinal epithelial cells involves Raf-independent signaling. Neoplasia. 2000 Jul-Aug;2(4):357-64. PubMed PMID: 11005570; PubMed Central PMCID: PMC1550294.
4. Emanuel PD, Snyder RC, Wiley T, Gopurala B, Castleberry RP. Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors. Blood. 2000 Jan 15;95(2):639-45. PubMed PMID: 10627474.