TargetMol

L 743310

Product Code:
 
TAR-T24359
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24359-5mg5mg£1,091.00
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TAR-T24359-50mg50mg£2,143.00
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Quantity:
TAR-T24359-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
L 743310 is an antagonist of the neurokinin-1 receptor.
CAS:
187724-86-3
Formula:
C30H33BrF6N4O2
Molecular Weight:
675.514
Purity:
0.98
SMILES:
[Br-].C[N+]12CCC(CC1)(CC2)NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F

References

1. Laird JM, Roza C, De Felipe C, Hunt SP, Cervero F. Role of central and peripheral tachykinin NK1 receptors in capsaicin-induced pain and hyperalgesia in mice. Pain. 2001 Feb 1;90(1-2):97-103. PubMed PMID: 11166975. 2. Robichaud A, Tattersall FD, Choudhury I, Rodger IW. Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret. Neuropharmacology. 1999 Feb;38(2):289-97. PubMed PMID: 10218871. 3. Tattersall FD, Rycroft W, Francis B, Pearce D, Merchant K, MacLeod AM, Ladduwahetty T, Keown L, Swain C, Baker R, Cascieri M, Ber E, Metzger J, MacIntyre DE, Hill RG, Hargreaves RJ. Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 1996;35(8):1121-9. PubMed PMID: 9121615.