L 858051
| Code | Size | Price |
|---|
| TAR-T24365-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24365-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24365-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes.
CAS:
110452-75-0
Formula:
C29H48N2O7
Molecular Weight:
536.71
Purity:
0.98
SMILES:
[H][C@@]12[C@H](O)[C@H](OC(=O)CCCN3CCN(C)CC3)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C
References
1. Belacel-Ouari M, Zhang L, Hubert F, Assaly R, Gerbier R, Jockers R, Dauphin F, Lech?ne P, Fischmeister R, Manoury B, Leblais V. Influence of cell confluence on the cAMP signalling pathway in vascular smooth muscle cells. Cell Signal. 2017 Jul;35:118-128. doi: 10.1016/j.cellsig.2017.03.025. Epub 2017 Apr 4. PubMed PMID: 28389413.
2. Haj Slimane Z, Bedioune I, Lech?ne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovasc Res. 2014 Apr 1;102(1):97-106. doi: 10.1093/cvr/cvu029. Epub 2014 Feb 18. PubMed PMID: 24550350; PubMed Central PMCID: PMC3958623.
3. Funaki C, Hodges RR, Dartt DA. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland. Am J Physiol Cell Physiol. 2007 Nov;293(5):C1551-60. Epub 2007 Aug 8. PubMed PMID: 17687004.
4. Rochais F, Vandecasteele G, Lefebvre F, Lugnier C, Lum H, Mazet JL, Cooper DM, Fischmeister R. Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels. J Biol Chem. 2004 Dec 10;279(50):52095-105. Epub 2004 Oct 1. PubMed PMID: 15466415.