TargetMol

Folinic acid

Product Code:
 
TAR-T24403
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24403-1mL1 mL * 10 mM (in DMSO)£111.00
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Quantity:
TAR-T24403-100mg100mg£151.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Leucovorin is the active metabolite of folic acid. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists.
CAS:
58-05-9
Formula:
C20H23N7O7
Molecular Weight:
473.446
Purity:
0.98
SMILES:
Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)N(C=O)c2c(=O)[nH]1

References

1. Damaske A, Ma N, Williams R. Leucovorin-induced hypersensitivity reaction. J Oncol Pharm Pract. 2012 Mar;18(1):136-9. doi: 10.1177/1078155210396577. Epub 2011 Jan 19. PubMed PMID: 21248170. 2. Ishihara S, Hayama T, Yamada H, Nozawa K, Matsuda K, Watanabe T. Benefit of tegafur-uracil and leucovorin in chemoradiotherapy for rectal cancer. Hepatogastroenterology. 2011 May-Jun;58(107-108):756-62. PubMed PMID: 21830385. 3. Saltz L, Badarinath S, Dakhil S, Bienvenu B, Harker WG, Birchfield G, Tokaz LK, Barrera D, Conkling PR, O'Rourke MA, Richards DA, Reidy D, Solit D, Vakiani E, Capanu M, Scales A, Zhan F, Boehm KA, Asmar L, Cohn A. Phase III trial of cetuximab, bevacizumab, and 5-fluorouracil/leucovorin vs. FOLFOX-bevacizumab in colorectal cancer. Clin Colorectal Cancer. 2012 Jun;11(2):101-11. doi: 10.1016/j.clcc.2011.05.006. Epub 2011 Nov 4. PubMed PMID: 22055112. 4. Budai B, Nagy T, L?ng I, Hitre E. The use of high dose d,l-leucovorin in first-line bevacizumab+mFOLFIRI treatment of patients with metastatic colorectal cancer may enhance the antiangiogenic effect of bevacizumab. Angiogenesis. 2013 Jan;16(1):113-21. doi: 10.1007/s10456-012-9303-z. Epub 2012 Sep 6. PubMed PMID: 22956187.