Men 10208
| Code | Size | Price |
|---|
| TAR-T24447-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Men 10208 is an antagonist of the neurokinin A receptor.
CAS:
129781-07-3
Formula:
C61H75N15O12
Molecular Weight:
1210.364
Purity:
0.98
SMILES:
CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
References
1. Medeiros MD, Turner AJ. Metabolic stability of some tachykinin analogues to cell-surface peptidases: roles for endopeptidase-24.11 and aminopeptidase N. Peptides. 1995;16(3):441-7. PubMed PMID: 7651897.
2. Patacchini R, Maggi CA. Amastatin interferes with the antagonist properties of MEN 10,208 in the rabbit pulmonary artery but not in the hamster trachea. Eur J Pharmacol. 1993 May 12;236(1):31-7. PubMed PMID: 8391454.
3. Henderson AK, Yamamura HI, Maggi CA, Buck SH, Van Giersbergen PL, Roeske WR. Demonstration of a neurokinin A receptor subtype in transfected fibroblasts. Eur J Pharmacol. 1992 Feb 13;225(2):175-8. PubMed PMID: 1312943.
4. Rovero P, Quartara L, Fabbri G. Solid-phase synthesis of neurokinin A antagonists. Comparison of the Boc and Fmoc methods. Int J Pept Protein Res. 1991 Feb;37(2):140-4. PubMed PMID: 1850390.