KI8751

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TargetMol
Product Code: TAR-T2446
Supplier: TargetMol
CodeSizePrice
TAR-T2446-2mg2mg£95.00
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TAR-T2446-5mg5mg£109.00
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TAR-T2446-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T2446-10mg10mg£133.00
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Quantity:
TAR-T2446-25mg25mg£197.00
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TAR-T2446-50mg50mg£319.00
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Quantity:
TAR-T2446-100mg100mg£507.00
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TAR-T2446-200mg200mg£638.00
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TAR-T2446-500mg500mg£938.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
CAS:
228559-41-9
Formula:
C24H18F3N3O4
Molecular Weight:
469.42
Pathway:
JAK/STAT signaling; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.999
SMILES:
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Target:
EGFR; VEGFR; FGFR; PDGFR; c-Kit

References

1. Kubo K, et al. J Med Chem, 2005, 48(5), 1359-1366. 2. Tamura D, et al. Cancer Sci, 2010, 101(6), 1403-1408. 3. Hasan MR, et al. Int J Cancer, 2011, 129(9), 2115?2123.