MRS2500
Code | Size | Price |
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TAR-T24497-5mg | 5mg | £1,332.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24497-50mg | 50mg | £2,625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24497-100mg | 100mg | £3,524.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
MRS2500 is a highly potent and selective platelet P2Y1 receptor antagonist.
CAS:
779323-43-2
Formula:
C13H18IN5O8P2
Molecular Weight:
561.166
Purity:
0.98
SMILES:
[H][C@]12C[C@@]1(COP(O)(O)=O)[C@H](CC2n1cnc2c(NC)nc(I)nc12)OP(O)(O)=O
References
1. Ciancetta A, O'Connor RD, Paoletta S, Jacobson KA. Demystifying P2Y(1) Receptor Ligand Recognition through Docking and Molecular Dynamics Analyses. J Chem Inf Model. 2017 Dec 26;57(12):3104-3123. doi: 10.1021/acs.jcim.7b00528. Epub 2017 Nov 28. PubMed PMID: 29182323.
2. Li Y, Yin C, Liu P, Li D, Lin J. Identification of a Different Agonist-Binding Site and Activation Mechanism of the Human P2Y(1) Receptor. Sci Rep. 2017 Oct 23;7(1):13764. doi: 10.1038/s41598-017-14268-1. PubMed PMID: 29062134; PubMed Central PMCID: PMC5653743.
3. Gao ZG, Jacobson KA. Distinct Signaling Patterns of Allosteric Antagonism at the P2Y(1) Receptor. Mol Pharmacol. 2017 Nov;92(5):613-626. doi: 10.1124/mol.117.109660. Epub 2017 Sep 1. PubMed PMID: 28864555; PubMed Central PMCID: PMC5635520.
4. Yen HY, Hopper JTS, Liko I, Allison TM, Zhu Y, Wang D, Stegmann M, Mohammed S, Wu B, Robinson CV. Ligand binding to a G protein-coupled receptor captured in a mass spectrometer. Sci Adv. 2017 Jun 16;3(6):e1701016. doi: 10.1126/sciadv.1701016. eCollection 2017 Jun. PubMed PMID: 28630934; PubMed Central PMCID: PMC5473672.